Structure of PDB 8cmk Chain B Binding Site BS02

Receptor Information
>8cmk Chain B (length=893) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YQAVQALYHDPSGKERASFWLGELQRSVEISDQLLQIRQDSCYFAAQTMK
MKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQ
MPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTE
IIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNF
MANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQ
LFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGL
GDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAY
IQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSME
CFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVR
LPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLAEKPLASA
AAKAIHNICSVCRDHMAQHFNGLLEIARSLDSFLLSPEAAVGLLKGTALV
LARLPLDKITECLSELCSVQVMALKKLLSQEPSSDPTVFLDRLAVIFRHT
NPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRC
VGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLL
DMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQV
VIPILQWAIASTTLDHRDANCSVMRFLRDLIHTGVANDHEEDFELRKELI
GQVMNQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWL
ENSLKGLPVTVTHKQLTDFHKQVTSAEECKQVCWALRDFTRLF
Ligand information
Receptor-Ligand Complex Structure
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PDB8cmk Tyrosine mediated nuclear import of CIRBP reveals a flexible NLS recognition by TNPO3
Resolution2.945 Å
Binding residue
(original residue number in PDB)		R620 E660 R664 R667 F668 R671 S698 C699 Y702 S705 I706 D709 D750 D751 R754 R758
Binding residue
(residue number reindexed from 1)		R598 E638 R642 R645 F646 R649 S676 C677 Y680 S683 I684 D687 D728 D729 R732 R736
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031267 small GTPase binding
GO:0042802 identical protein binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
GO:0015031 protein transport
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005642 annulate lamellae
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cmk, PDBe:8cmk, PDBj:8cmk
PDBsum8cmk
PubMed
UniProtQ9Y5L0|TNPO3_HUMAN Transportin-3 (Gene Name=TNPO3)

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