Structure of PDB 8cls Chain B Binding Site BS02

Receptor Information
>8cls Chain B (length=853) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLNRSFPKLTE
VTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGL
HKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKEC
RLSKCPGEIRSCQLHNNRRLCWNSKLCQTKCPEKCRNNCIDEHTCCSQDC
LGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFDSRCVTANECITL
TKFETNSVYSGIPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKECSSG
LIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQ
SSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGP
NQTVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGN
RGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAF
IGFVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYS
YYVRTMAISSELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWS
YLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVEYDDRKVQAGMEFE
NALQNFIFVPKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLR
HFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIV
MDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKK
CIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPS
YAK
Ligand information
>8cls Chain D (length=27) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
NSLRACGPALMDMLRVACPNGFNSMFA
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cls Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		S341 M342 D343 R345 F363 D367 L368 R393
Binding residue
(residue number reindexed from 1)		S7 M8 D9 R11 F29 D33 L34 R59
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:8cls, PDBe:8cls, PDBj:8cls
PDBsum8cls
PubMed37805602
UniProtP09208|INSR_DROME Insulin-like receptor (Gene Name=InR)

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