Structure of PDB 8bf5 Chain B Binding Site BS02

Receptor Information
>8bf5 Chain B (length=726) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEY
SNKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEH
PGLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITS
FRLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLFLIKRIPM
KVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIRGFVLVVE
NLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGISMTVTGDN
TKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIARLGKGFM
ITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEEGTASLSP
GMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALFVNAKDEE
TCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDGFVSNFAM
ELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQLFIADYRY
TYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYNLRNLHIP
EIVLKYNLMDPEYKGRLLHPQNPFVGHLSKMDYDAVSGTHSWRTKRNRSI
LNTDQRNMILEEQCYAKCCNLFEACFNSASYRKPVGQHSMLEAMAHRLRM
DARLDYESGRMSKDDFEKAMAHLGEI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8bf5 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Resolution2.96 Å
Binding residue
(original residue number in PDB)		R126 Q127 N136 M227 K229 D230 I241 A242 R249 P272 V273 G274 G275 M412 N414 M415 I524 T527 N531
Binding residue
(residue number reindexed from 1)		R127 Q128 N137 M221 K223 D224 I235 A236 R243 P266 V267 G268 G269 M406 N408 M409 I518 T521 N525
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bf5, PDBe:8bf5, PDBj:8bf5
PDBsum8bf5
PubMed36596301
UniProtQ5V8Y6

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