Structure of PDB 8b7e Chain B Binding Site BS02

Receptor Information
>8b7e Chain B (length=1122) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVG
WLTNMHATLVSQENQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDES
RVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSN
QLFEARKLLRPILQDNANNNVQRNIYNVVDAKHLIEDIREYDVPYHVRVS
IDKDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFAIATTKPPLKFPDSA
VDQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNEND
EVALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGF
APDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIEL
DPELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNP
DETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYV
GGHVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSV
DKVTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRL
QPDSIKAERDCTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKNK
FSKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQ
RENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIV
LYDSLQLAHKVILVSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARAL
VERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSMLNYRV
HQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKG
IKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEG
CYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKS
TSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSA
DIPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAAL
QGVSNPVPRVEHPDWLKRKIAT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8b7e A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K510 G511 T512 G513 T514 T552 Y553 G555 G556 V558 R686 R744 H748 S829 G832 M835 R836 K837 I965 K966 K967 R988 K1063 T1103 Y1145 K1156
Binding residue
(residue number reindexed from 1)		K456 G457 T458 G459 T460 T498 Y499 G501 G502 V504 R622 R680 H684 S765 G768 M771 R772 K773 I901 K902 K903 R924 K999 T1039 Y1081 K1092
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b7e, PDBe:8b7e, PDBj:8b7e
PDBsum8b7e
PubMed37819038
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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