Structure of PDB 8b76 Chain B Binding Site BS02

Receptor Information
>8b76 Chain B (length=1121) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVG
WLTNMHATLVSQENQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDES
RVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSN
QLFEARKLLRPILQDNANNNVQRNIYNVDAKHLIEDIREYDVPYHVRVSI
DKDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAV
DQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDE
VALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFA
PDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELD
PELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPD
ETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVG
GHVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVD
KVTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASGYPNIMTTNRLQ
PDSIKAERDCTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKNKF
SKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQR
ENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVL
YDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALV
ERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSMLNYRVH
QKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKGI
KKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEGC
YSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKST
SITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSAD
IPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQ
GVSNPVPRVEHPDWLKRKIAT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8b76 A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K510 G511 T512 G513 T514 T552 Y553 G555 G556 R686 R744 S829 G832 M835 R836 K837 I965 K966 K967 R988 T1103 Y1145 R1149 K1156
Binding residue
(residue number reindexed from 1)		K455 G456 T457 G458 T459 T497 Y498 G500 G501 R621 R679 S764 G767 M770 R771 K772 I900 K901 K902 R923 T1038 Y1080 R1084 K1091
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b76, PDBe:8b76, PDBj:8b76
PDBsum8b76
PubMed37819038
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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