Structure of PDB 8att Chain B Binding Site BS02

Receptor Information

>8att Chain B (length=340) Species: 559292 (Saccharomyces cerevisiae S288C)

SVPIPGIKDISKLKFFYGFKYLWNPTVYNKIFDKLDLTKTYKHPEELKVL
DLYPGVGIQSAIFYNKYCPRQYSLLEKRSSLYKFLNAKFEGSPLQILKRD
PYDWSTYSNLIDEERIFVPEVQSSDHINDKFLTVANVTGEGSEGLIMQWL
SCIGNKNWLYRFGKVKMLLWMPSTTARKLLARPGMHSRSKCSVVREAFTD
TKLIAISDANELKGFDSQCIEEWDPILFSAAEIWPTKGKPIALVEMDPID
FDFDVDNWDYVTRHLMILKRTPLNTVMDSLGHGGQQYFNSRITDKDLLKK
CPIDLTNDEFIYLTKLFMEWPFKPDILMDFVDMYQTEHSG

Ligand information

>8att Chain T (length=26)

cattatctaccgcaatatcaatactt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8att Structures illustrate step-by-step mitochondrial transcription initiation
• Resolution: 3.44 Å
• Binding residue (original residue number in PDB): H187 L269 K270 R271 M334 H339 G341
• Binding residue (residue number reindexed from 1): H186 L268 K269 R270 M333 H338 G340

Enzymatic activity

• Enzyme Commision number: 2.1.1.-

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0008168 methyltransferase activity
• GO:0034246 mitochondrial transcription factor activity

Biological Process

• GO:0006390 mitochondrial transcription
• GO:0006391 transcription initiation at mitochondrial promoter
• GO:0032259 methylation
• GO:0032786 positive regulation of DNA-templated transcription, elongation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005758 mitochondrial intermembrane space
• GO:0005759 mitochondrial matrix
• GO:0034245 mitochondrial DNA-directed RNA polymerase complex

External links

• PDB: RCSB:8att, PDBe:8att, PDBj:8att
• PDBsum: 8att
• PubMed: 37821701
• UniProt: P14908|MTF1_YEAST Mitochondrial transcription factor 1 (Gene Name=MTF1)