Structure of PDB 8alk Chain B Binding Site BS02

Receptor Information
>8alk Chain B (length=163) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTVDFKIRTIELDGKTIKL
QIWDTAGQERFRTITSTYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRY
AENVNKLLVGNKSDLTTKKVVDNTTAKEFADSLGIPFLETSAKNATNVEQ
AFMTMAAEIKKRM
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8alk Chain B Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8alk Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		S22 D44 D63
Binding residue
(residue number reindexed from 1)		S21 D35 D54
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:8alk, PDBe:8alk, PDBj:8alk
PDBsum8alk
PubMed37076474
UniProtQ9H0U4|RAB1B_HUMAN Ras-related protein Rab-1B (Gene Name=RAB1B)

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