Structure of PDB 7zvv Chain B Binding Site BS02

Receptor Information
>7zvv Chain B (length=154) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLD
PYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIF
KTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAIT
QGKR
Ligand information
Ligand ID4CF
InChIInChI=1S/C10H10N2O2/c11-6-8-3-1-7(2-4-8)5-9(12)10(13)14/h1-4,9H,5,12H2,(H,13,14)/t9-/m0/s1
InChIKeyKWIPUXXIFQQMKN-VIFPVBQESA-N
SMILES
SoftwareSMILES
CACTVS 3.370N[C@@H](Cc1ccc(cc1)C#N)C(O)=O
CACTVS 3.370N[CH](Cc1ccc(cc1)C#N)C(O)=O
OpenEye OEToolkits 1.7.0c1cc(ccc1CC(C(=O)O)N)C#N
OpenEye OEToolkits 1.7.0c1cc(ccc1C[C@@H](C(=O)O)N)C#N
ACDLabs 12.01O=C(O)C(N)Cc1ccc(C#N)cc1
FormulaC10 H10 N2 O2
Name4-cyano-L-phenylalanine
ChEMBL
DrugBank
ZINCZINC000004202289
PDB chain7zvv Chain B Residue 204 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zvv Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2196
Resolution1.75 Å
Binding residue
(original residue number in PDB)		G153 Y161
Binding residue
(residue number reindexed from 1)		G137 Y145
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7zvv, PDBe:7zvv, PDBj:7zvv
PDBsum7zvv
PubMed38809037
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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