Structure of PDB 7zkn Chain B Binding Site BS02

Receptor Information
>7zkn Chain B (length=252) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
GE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zkn A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers.
Resolution3.03 Å
Binding residue
(original residue number in PDB)		I24 R75 Y76 E77 R77A I79 Y117
Binding residue
(residue number reindexed from 1)		I9 R70 Y71 E72 R73 I75 Y114
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:7zkn, PDBe:7zkn, PDBj:7zkn
PDBsum7zkn
PubMed36457701
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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