Structure of PDB 7zeh Chain B Binding Site BS02

Receptor Information
>7zeh Chain B (length=275) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STLMKATVLMRQPGRVQEIVGALRKGGGDRLQVISDFDMTLSRFAYNGKR
CPSSYNILDNSKIISEECRKELTALLHHYYPIEIDPHRTVKEKLPHMVEW
WTKAHNLLCQQKIQKFQIAQVVRESNAMLREGYKTFFNTLYHNNIPLFIF
SAGIGDILEEIIRQMKVFHPNIHIVSNYMDFNEDGFLQGFKGQLIHTYNK
NSSAEGKTNVILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYM
DSYDIVLEKDETLDVVNGLLQHILC
Ligand information
Ligand IDRBL
InChIInChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5-/m1/s1
InChIKeyZAQJHHRNXZUBTE-NQXXGFSBSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(CO)C(O)C(O)CO
OpenEye OEToolkits 1.5.0C(C(C(C(=O)CO)O)O)O
OpenEye OEToolkits 1.5.0C([C@H]([C@H](C(=O)CO)O)O)O
CACTVS 3.341OC[C@@H](O)[C@@H](O)C(=O)CO
CACTVS 3.341OC[CH](O)[CH](O)C(=O)CO
FormulaC5 H10 O5
NameD-ribulose
ChEMBLCHEMBL195989
DrugBank
ZINCZINC000000902225
PDB chain7zeh Chain B Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7zeh Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		E88 T202
Binding residue
(residue number reindexed from 1)		E83 T197
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.5: 5'-nucleotidase.
3.1.3.91: 7-methylguanosine nucleotidase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005515 protein binding
GO:0008253 5'-nucleotidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0009117 nucleotide metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zeh, PDBe:7zeh, PDBj:7zeh
PDBsum7zeh
PubMed35631380
UniProtQ969T7|5NT3B_HUMAN 7-methylguanosine phosphate-specific 5'-nucleotidase (Gene Name=NT5C3B)

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