Structure of PDB 7yxg Chain B Binding Site BS02

Receptor Information
>7yxg Chain B (length=312) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASMSEVERALDVLLQEAEELCIGSSVVELDRIPTALEFCREFYSKNQPVV
IRKALNWPAIGKWTPKYLIEALGDRSVDVAITPNGYADGLATQNGQEYFV
LPLETKMKLSEVVRRLDDPTGAVHYIQKQNSNLSVDLPELAADLRVSDLD
FAQQSFNKPPDAVNFWLGDERAVTSMHKDPYENVYCVISGHKDFVLIPPH
QLSCVPRGIYPTGVYKTSDSGQFYIEPLRDEDQFTEWVSVDPLSPDLAKY
PEYARAKPLKVRVHAGDILYLPNYWFHHVSQSHKCIAVNFWYDLDYDSRY
CYYRMLEQMTSA
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain7yxg Chain B Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7yxg Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans.
Resolution1.641 Å
Binding residue
(original residue number in PDB)		Y123 W164 T172 H175 N181 Y183 K190 H278 V280 N290 W292
Binding residue
(residue number reindexed from 1)		Y125 W166 T174 H177 N183 Y185 K192 H277 V279 N289 W291
Annotation score5
Enzymatic activity
Enzyme Commision number 1.14.11.-
3.1.1.4: phospholipase A2.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0106155 peptidyl-lysine 3-dioxygenase activity
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:7yxg, PDBe:7yxg, PDBj:7yxg
PDBsum7yxg
PubMed35410347
UniProtQ9VU77

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