Structure of PDB 7y7r Chain B Binding Site BS02

Receptor Information

>7y7r Chain B (length=897) Species: 5141 (Neurospora crassa)

AALRNIWPKFPKWHEAPLAVAWEVTRFMHKVDSLGLKYDPSTARDVTDIE
KPPNDVFVTAMTGNFESKGSAVVLSAVLDYNPDNSPLYLVKLKPLMFEQG
CRLTRRFGPDRFFEILIPSPTSSPSVPPVSKQAVEEVIQWLTMGQHSLVG
RQWRAFFAKDAGYRKPPIIKERVHFFAETGITFRPDEPVEQRTEFKVSQM
LDWLLQLDNNTWQPHLKLFSRIQLGLSKTYAIMTLEPHQIRHHKTDLLSP
SGTGEVMNDGVGRMSRSVAKRIRDVLGLGDVPSAVQGRFGSAKGMWVIDV
DDTGDEDWIETYPSQRKWECDFVDKHQRTLEVRSVASELKSAGLNLQLLP
VLEDRARDKVKMRQAIGDRLINDLQRQFSEQKHALNRPVEFRQWVYESYS
SRATRVSHGRVPFLAGLPDSQEETLNFLMNSGFDPKKQKYLQDIAWDLQK
RKCDTLKSKLNIRVGRSAYIYMIADFWGVLEENEVHVGFSSKFRDEESFT
LLSDCDVLVARSPAHFPSDIQRVRAVFKPELHSLKDVIIFSTKGDVPLAK
KLSGGDYDGDMAWVCWDPEIVDGFVNAEMPLEPDLSRYLKKDKTTFKQLM
ASHGTGSAAKEQTTYDMIQKSFHFALQPNFLGMCTNYKERLCYINNSVSN
KPAIILSSLVGNLVDQSKQGIVFNEASWAQLRRELLGGALSLPDPMYKSD
SWLGRGEPTHIIDYLKFSIARPAIDKELEAFHNMKAADGAHFWDPDLASY
YTFFKEISDKSRSSALLFTTLKNRIGEVEKEYGRLVKKEDPYPVRVNQVY
EKWCAITPSKVIRLLELSFLADREMNTWALLRASTAFKLYYHKSPKFVWQ
MAGRQLAYIKAQMTSRPGEGAPALMTAFMYAGLMPDKKFTKQYVARL

Ligand information

>7y7r Chain F (length=5)

cgacg

.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7y7r Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): R591 S677 K678 Q736 R738 R783 D1011
• Binding residue (residue number reindexed from 1): R164 S227 K228 Q286 R288 R333 D560

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity

External links

• PDB: RCSB:7y7r, PDBe:7y7r, PDBj:7y7r
• PDBsum: 7y7r
• PubMed: 36039765
• UniProt: Q9Y7G6