Structure of PDB 7y1t Chain B Binding Site BS02

Receptor Information
>7y1t Chain B (length=345) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INTQVTPGEVSIQLRPGAEANFMLKVHPLKKYPVDLYYLVDVSASMHNNI
EKLNSVGNDLSRKMAFFSRDFRLGFGSYVDKTVSPYISIHPERIHNQCSD
YNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQA
AVCESHIGWRKEAKRLLLVMTDQTSHLALDSKLAGIVCPNDGNCHLKNNV
YVKSTTMEHPSLGQLSEKLIDNNINVIFAVQGKQFHWYKDLLPLLPGTIA
GEIESKAANLNNLVVEAYQKLISEVKVQVENQVQGIYFNITAICPDGSRK
PGMEGCRNVTSNDEVLFNVTVTMKNYAIIKPIGFNETAKIHIHRN
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7y1t Chain B Residue 505 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7y1t Specificity of TGF-beta 1 signal designated by LRRC33 and integrin alpha V beta 8.
Resolution3.24 Å
Binding residue
(original residue number in PDB)		S114 S116 E212 Q244
Binding residue
(residue number reindexed from 1)		S43 S45 E141 Q173
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:7y1t, PDBe:7y1t, PDBj:7y1t
PDBsum7y1t
PubMed36008481
UniProtP26012|ITB8_HUMAN Integrin beta-8 (Gene Name=ITGB8)

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