Structure of PDB 7xt7 Chain B Binding Site BS02

Receptor Information
>7xt7 Chain B (length=1164) Species: 460519 (Komagataella phaffii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDTITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLIL
DQPAQHDNINKRYEIRFGKIYLSRPTMTEADGTTHAMFPQEARLRNLTYS
SPVYLDMEKSMFTSIDGNKVHIGKVPIMLRSKFCSLRTLDEVDLYKMKEC
PYDMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIRSALE
KGSRLISTMQIKLYGREDKGTGRTIKATLPYVKQDIPIVIVFRALGVVPD
GEILQHICYDENDWQMLEMLKPCIEEGFVIQDKEVALDFIGRRGSAALGI
RREKRIQYAKDILQKELLPHITQEEGFETRKTFFLGYMVNRLLLCALERK
DQDDRDHFGKKRLDLAGPLLANLFRILFRKLTREIYRYMQRCIETDRDFN
LNLAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLS
HLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLLS
GISIGSPSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGIHRDP
SMLVSTMRDLRRSGAISPEVSIIRDIREREFKIFTDVGRVYRPLFIVEDD
ESKDNKGELRITKEHIRKIQQGYDDDVYGWSSLVTSGVIEYVDGEEEETI
MIAMTPEDLQTNDTAKRIKPEMSTSSHHTFTHCEIHPSMILGVAASIIPF
PDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLAKTQA
MEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRS
YMDQEKRFGISIVEEFEKPTRATTLRLKHGTYEKLDEDGLIAPGVRVSGD
DIIIGKTTPIPPDTEELGQRTKYHTKRDASTPLRSTENGIVDQVLLTTNQ
EGLKFVKVRMRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSAEGIVP
DLIINPHAIPSRMTVAHLIECLLSKVGSIRGYEGDATPFTDLTVDAVSNL
LRDNGYQSRGFEVMYNGHTGKKLMAQVFFGPTYYQRLRHMVDDKIHARAR
GPVQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAGFLKERLMEASDAF
RVHVCGICGLMSVIANLKKNQFECRSCKNKTNIYQLHIPYAAKLLFQELM
AMNIAPRLYTERSG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7xt7 Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		Q474 Q776 R879 K886 H887 K979 K987 H1097 R1124
Binding residue
(residue number reindexed from 1)		Q438 Q718 R821 K828 H829 K921 K929 H1039 R1066
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xt7, PDBe:7xt7, PDBj:7xt7
PDBsum7xt7
PubMed35981082
UniProtC4QZQ7

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