Structure of PDB 7xsr Chain B Binding Site BS02

Receptor Information
>7xsr Chain B (length=1287) Species: 237368 (Candidatus Scalindua brodae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DMNITVELTFFEPYRLVEWFDWDARKKSHSAMRGQAFAQWTWKGKGRTAG
KSFITGTLVRSAVIKAVEELLSLNNGKWEGVPCCNGSFQTDESKGKKPSF
LRKRHTLQWQANNKNICDKEEACPFCILLGRFDNAGKVHERNKDYDIHFS
NFDLDHKQEKNDLRLVDIASGRILNRVDFDTGKAKDYFRTWEADYETYGT
YTGRITLRNEHAKKLLLASLGFVDKLCGALCRIEVIKSEDHNDELRKQAE
VIVEAFKQNDKLEKIRILADAIRTLRLHGEGVIEKDELPDGKEERDKGHH
LWDIKVQGTALRTKLKELWQSNKDIGWRKFTEMLGSNLYLIYKKETGGVS
TRFRILGDTEYYSKAHDSEGSDLFIPVTPPEGIETKEWIIVGRLKAATPF
YFGVQQPSDSIPGKEKKSEDSLVINEHTSFNILLDKENRYRIPRSALRGA
LRRDLRTAFGSGCNVSLGGQILCNCKVCIEMRRITLKDSVSDFSEPPEIR
YRIAKNPGTATVEDGSLFDIEVGPEGLTFPFVLRYRGHKFPEQLSSVIRY
WEENDGKNGMAWLGGLDSTGKGRFALKDIKIFEWDLNQKINEYIKERGMR
GKEKELLEMGESSLPDGLIPYKFFEERECLFPYKENLKPQWSEVQYTIEV
GSPLLTADTISALTEPGNRDAIAYKKRVYNDGNNAIEPEPRFAVKSETHR
GIFRTAVGRRTGDLGKEDHEDCTCDMCIIFGNEHESSKIRFEDLELINGN
EFEKLEKHIDHVAIDRFTGGALDKAKFDTYPLAGSPKKPLKLKGRFWIKK
GFSGDHKLLITTALSDIRDGLYPLGSKGGVGYGWVAGISIDDNVPDDFKE
MINKTEGPINNDYVHPGHQSPKQDHKNKNIYYPHYFLDSGSKVYREKDII
THEEFTEELLSGKINCKLETLTPLIIPDTSDENGLKLQGNKPGHKNYKFF
NINGELMIPGSELRGMLRTHFEALTKSCFAIFGEDSTKTLGGKLDKALHP
CTGLSDGLCPGCHLFGTTDYKGRVKFGFAKYENGPEWLITRGNNPERSLT
LGVLESPRPAFSIPDDESEIPGRKFYLHHNGWRIIRQKQLEIRETVQPER
NVTTEVMDKGNVFSFDVRFENLREWELGLLLQSLDPGKNIAHKLGKGKPY
GFGSVKIKIDSLHTFKINSNNDKIKRVPQSDIREYINKGYQKLIEWSGNN
SIQKGNVLPQWHVIPHIDKLYKLLWVPFLNDSKLEPDVRYPVLNEESKGY
IEGSDYTYKKLGDKDNLPYKTRVKGLTTPWSPWNPFQ
Ligand information
>7xsr Chain D (length=34) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gacuuaaugucacgguacccaauuuucugccccg
..................................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7xsr Target RNA activates the protease activity of Craspase to confer antiviral defense.
Resolution2.97 Å
Binding residue
(original residue number in PDB)
W23 R37 F41 T45 R64 S65 S91 F92 Q93 T94 P102 S103 F104 L105 R106 K107 R108 G134 D137 K141 H143 Y149 H152 F153 N155 D157 I177 L178 N179 V181 G186 K187 D190 F192 Y389 S391 D400 G431 R472 S473 R476 R481 S494 L495 L500 L514 R530 I531 K533 T539 F546 G593 S596 E725 R728 R732 N760 S765 D788 H789 V790 I792 R794 K804 F805 S854 Y922 P967 T969 S1001 E1002 R1004 R1008 T1422 T1423 K1426 L1459 E1460 R1463 F1466 K1553 P1554 Y1645 L1648 Y1663
Binding residue
(residue number reindexed from 1)
W19 R33 F37 T41 R60 S61 S87 F88 Q89 T90 P98 S99 F100 L101 R102 K103 R104 G130 D133 K137 H139 Y145 H148 F149 N151 D153 I173 L174 N175 V177 G182 K183 D186 F188 Y361 S363 D372 G403 R444 S445 R448 R453 S466 L467 L472 L486 R502 I503 K505 T511 F518 G565 S568 E697 R700 R704 N732 S737 D760 H761 V762 I764 R766 K776 F777 S826 Y882 P927 T929 S961 E962 R964 R968 T1017 T1018 K1021 L1054 E1055 R1058 F1061 K1148 P1149 Y1240 L1243 Y1258
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:7xsr, PDBe:7xsr, PDBj:7xsr
PDBsum7xsr
PubMed36306795
UniProtA0A0B0EGF3

[Back to BioLiP]