Structure of PDB 7xbz Chain B Binding Site BS02

Receptor Information

>7xbz Chain B (length=187) Species: 1280 (Staphylococcus aureus)

LIPTVIETGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQD
SEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLA
AGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILS
ERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVP

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7xbz Chain B Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7xbz Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP.
• Resolution: 2.15 Å
• Binding residue (original residue number in PDB): I81 P86
• Binding residue (residue number reindexed from 1): I76 P81
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.21.92: endopeptidase Clp.

Gene Ontology

Molecular Function

• GO:0004176 ATP-dependent peptidase activity
• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0051117 ATPase binding

Biological Process

• GO:0006508 proteolysis
• GO:0006515 protein quality control for misfolded or incompletely synthesized proteins

Cellular Component

• GO:0005737 cytoplasm
• GO:0009368 endopeptidase Clp complex

External links

• PDB: RCSB:7xbz, PDBe:7xbz, PDBj:7xbz
• PDBsum: 7xbz
• PubMed: 36376309
• UniProt: Q2G036|CLPP_STAA8 ATP-dependent Clp protease proteolytic subunit (Gene Name=clpP)