Structure of PDB 7wzv Chain B Binding Site BS02

Receptor Information
>7wzv Chain B (length=297) Species: 68270 (Streptomyces spectabilis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRLADGKVRNPEGIEVNASLQCNMRCQSCAHLSPLYRRENADPAEIHDTL
SVLARSYHASYAKIMGGEPLLHPDVVGLIEAVRATGISDTVLVATNGTLL
HRATERFWQAVDSLEISVYPSRMIAPEEIERYRVLAREHGVSLLVNYYGH
FRAVYSESGTDAPDLVRDVFDTCKLAHFWNSHTVYDGWLYRCPQSVFMPR
QLRDGGWDPRVDGLRIEDDPAFLERLHRFLTADDPLRACRNCLGSVGKLH
PHQELPRAGWQVTEQLAALVDYPFLKVCKDDITADDGCVERSLSAPV
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7wzv Chain B Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7wzv Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.
Resolution1.89931 Å
Binding residue
(original residue number in PDB)		C24 M26 C28 C31 S35 P36 G69 N98 Y121 F153
Binding residue
(residue number reindexed from 1)		C22 M24 C26 C29 S33 P34 G67 N96 Y119 F151
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding

View graph for
Molecular Function
External links
PDB RCSB:7wzv, PDBe:7wzv, PDBj:7wzv
PDBsum7wzv
PubMed35622017
UniProtA8WEZ7

[Back to BioLiP]