Structure of PDB 7wvj Chain B Binding Site BS02

Receptor Information
>7wvj Chain B (length=659) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLT
SLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDDTFAFCTNLTEL
HLMSNSIQKIDNNPFVDQKNLITLDLSHNGLSSTKLGTQVQLENLQELLL
SNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFL
NNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTM
LDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLN
LKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGL
INLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFS
WLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFAL
VPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEG
LEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIP
VEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKK
VFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCN
TPPHYHGFP
Ligand information
>7wvj Chain F (length=46) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wvj TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand.
Resolution3.26 Å
Binding residue
(original residue number in PDB)		K41 H60 Q62 R544 K619
Binding residue
(residue number reindexed from 1)		K13 H32 Q34 R516 K591
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wvj, PDBe:7wvj, PDBj:7wvj
PDBsum7wvj
PubMed36371424
UniProtO15455|TLR3_HUMAN Toll-like receptor 3 (Gene Name=TLR3)

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