Structure of PDB 7wnu Chain B Binding Site BS02

Receptor Information
>7wnu Chain B (length=554) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPPPGPLTSGGLRVTALGGINEIGRNMTVFEHLGRLLIIDCGVLFPGHDE
PGVDLILPDMRHVEDRLDDIEALVLTHGHEDHIGAIPFLLKLRPDIPVVG
SKFTLALVAEKCREYRITPVFVEVREGQSTRHGVFECEYFAVNHSTPDAL
AIAVYTGAGTILHTGDIKFDQLPPDGRPTDLPGMSRLGDTGVDLLLCDST
NAEIPGVGPSESEVGPTLHRLIRGADGRVIVACFASNVDRVQQIIDAAVA
LGRRVSFVGRSMVRNMRVARQLGFLRVADSDLIDIAAAETMAPDQVVLIT
TGTQGEPMSALSRMSRGEHRSITLTAGDLIVLSSSLIPGNEEAVFGVIDA
LSKIGARVVTNAQARVHVSGHAYAGELLFLYNGVRPRNVMPVHGTWRMLR
ANAKLAASTGVPQESILLAENGVSVDLVAGKASISGAVPVGKMFVDGLIA
GDVGDITLGERLILSSGFVAVTVVVRRGTGQPLAAPHLHSRGFSEDPKAL
EPAVRKVEAELESLVAANVTDPIRIAQGVRRTVGKWVGETYRRQPMIVPT
VIEV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7wnu Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7wnu Structural ans functional study of RNase J from Mycobacterium tuberculosis
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H86 D170 H397
Binding residue
(residue number reindexed from 1)		H82 D166 H393
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
3.5.2.6: beta-lactamase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0004527 exonuclease activity
GO:0004534 5'-3' RNA exonuclease activity
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
GO:0046872 metal ion binding
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7wnu, PDBe:7wnu, PDBj:7wnu
PDBsum7wnu
PubMed
UniProtP9WGZ9|RNJ_MYCTU Ribonuclease J (Gene Name=rnj)

[Back to BioLiP]