Structure of PDB 7wbx Chain B Binding Site BS02

Receptor Information
>7wbx Chain B (length=1157) Species: 460519 (Komagataella phaffii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDTITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLIL
DQPAQHDNINKRYEIRFGKIYLSRPTMTEADGTTHAMFPQEARLRNLTYS
SPVYLDMEKSMFTSIDGNKVHIGKVPIMLRSKFCSLRTLDEVDLYKMKEC
PYDMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIRSALE
KGSRLISTMQIKLYGREDKGTGRTIKATLPYVKQDIPIVIVFRALGVVPD
GEILQHICYDENDWQMLEMLKPCIEEGFVIQDKEVALDFIGRRGSAALGI
RREKRIQYAKDILQKELLPHITQEEGFETRKTFFLGYMVNRLLLCALERK
DQDDRDHFGKKRLDLAGPLLANLFRILFRKLTREIYRYMQRCIETDRDFN
LNLAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLS
HLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLLS
GISIGSPSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGIHRDP
SMLVSTMRDLRRSGAISPEVSIIRDIREREFKIFTDVGRVYRPLFIVEDD
ESKDNKGELRITKEHIRKIQQGYDDDVYGWSSLVTSGVIEYVDGEEEETI
MIAMTPEDLQTRSLNDTAKRIKPEMSTSSHHTFTHCEIHPSMILGVAASI
IPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLAK
TQAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLF
FRSYMDQEKRFGISIVEEFEKPTRATTLRLKHGTYEKLDEDGLIAPGVRV
SGDDIIIGKTTPIPPYHTKRDASTPLRSTENGIVDQVLLTTNQEGLKFVK
VRMRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSAEGIVPDLIINPH
AIPSRMTVAHLIECLLSKVGSIRGYEGDATPFTDLTVDAVSNLLRDNGYQ
SRGFEVMYNGHTGKKLMAQVFFGPTYYQRLRHMVDDKIHARARGPVQVLT
RQPVEGRSRDGGLRFGEMERDCMIAHGAAGFLKERLMEASDAFRVHVCGI
CGLMSVIANLKKNQFECRSCKNKTNIYQLHIPYAAKLLFQELMAMNIAPR
LYTERSG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7wbx Structural Basis of Damaged Nucleotide Recognition by Transcribing RNA Polymerase II in the Nucleosome.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		Q776 R884 K886 H887 K979 K987 H1097
Binding residue
(residue number reindexed from 1)		Q721 R829 K831 H832 K914 K922 H1032
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7wbx, PDBe:7wbx, PDBj:7wbx
PDBsum7wbx
PubMed37120012
UniProtC4QZQ7

[Back to BioLiP]