Structure of PDB 7vgf Chain B Binding Site BS02

Receptor Information
>7vgf Chain B (length=550) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMVATMATAVLI
GYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSR
QTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFA
LVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVK
YFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMV
LASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTL
FTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKVLSGISFE
VPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESL
RRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRM
PHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITE
ETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7vgf Chain B Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7vgf Cryo-EM structure of AMP-PNP-bound human mitochondrial ATP-binding cassette transporter ABCB7.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		S512 Q553
Binding residue
(residue number reindexed from 1)		S368 Q409
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015232 heme transmembrane transporter activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0140359 ABC-type transporter activity
GO:0140481 ABC-type iron-sulfur cluster transporter activity
Biological Process
GO:0006879 intracellular iron ion homeostasis
GO:0015886 heme transport
GO:0016226 iron-sulfur cluster assembly
GO:0034755 iron ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070455 positive regulation of heme biosynthetic process
GO:0140466 iron-sulfur cluster export from the mitochondrion
GO:1903331 positive regulation of iron-sulfur cluster assembly
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vgf, PDBe:7vgf, PDBj:7vgf
PDBsum7vgf
PubMed
UniProtO75027|ABCB7_HUMAN Iron-sulfur clusters transporter ABCB7, mitochondrial (Gene Name=ABCB7)

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