Structure of PDB 7ujp Chain B Binding Site BS02

Receptor Information
>7ujp Chain B (length=267) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQK
LEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY
YSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLAD
FGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL
LVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP
SKRITAAEALKHPWISH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ujp CaMKII binds both substrates and activators at the active site.
Resolution2.56 Å
Binding residue
(original residue number in PDB)		E96 F98 E99 N135 E139 L159 F173 A174 G175 T176 P177 G178 Y210 P211 Q218 E236
Binding residue
(residue number reindexed from 1)		E90 F92 E93 N129 E133 L153 F167 A168 G169 T170 P171 G172 Y204 P205 Q212 E230
Enzymatic activity
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ujp, PDBe:7ujp, PDBj:7ujp
PDBsum7ujp
PubMed35830796
UniProtQ9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)

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