Structure of PDB 7uj4 Chain B Binding Site BS02

Receptor Information
>7uj4 Chain B (length=447) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLKTAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGL
RDVHLALSEDHAWVVFGPNGEQTAEVTWHGRGQTVNAGVAERSWLYLKGS
YMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERY
PMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAG
YHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLL
KEAASLLEAGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLV
QSLGRFEGQVRQKVRITFQSEKMKGMKELLVATKINSSAIKLQLTAQ
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7uj4 Chain B Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7uj4 MEN1 mutations mediate clinical resistance to menin inhibition.
Resolution1.96 Å
Binding residue
(original residue number in PDB)		D180 E359
Binding residue
(residue number reindexed from 1)		D160 E333
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:7uj4, PDBe:7uj4, PDBj:7uj4
PDBsum7uj4
PubMed36922589
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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