Structure of PDB 7uir Chain B Binding Site BS02

Receptor Information
>7uir Chain B (length=261) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSE
ADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASGAAVKLADFGLAIE
VEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPP
FWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITA
AEALKHPWISH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7uir CaMKII binds both substrates and activators at the active site.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		F98 E105 K137 E139 G175 T176 G178 Y179 V208 G209 Y210 W214 P233 E236
Binding residue
(residue number reindexed from 1)		F89 E96 K128 E130 G163 T164 G166 Y167 V196 G197 Y198 W202 P221 E224
Enzymatic activity
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7uir, PDBe:7uir, PDBj:7uir
PDBsum7uir
PubMed35830796
UniProtQ9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)

[Back to BioLiP]