Structure of PDB 7uiq Chain B Binding Site BS02

Receptor Information
>7uiq Chain B (length=261) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEA
DASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLAAVKLADFGLAIE
VEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPP
FWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITA
AEALKHPWISH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7uiq CaMKII binds both substrates and activators at the active site.
Resolution3.11 Å
Binding residue
(original residue number in PDB)		E96 F98 E99 E105 K137 E139 F173 G175 T176 V208 G209 Y210 W214 P233 E236
Binding residue
(residue number reindexed from 1)		E86 F88 E89 E95 K127 E129 F161 G163 T164 V196 G197 Y198 W202 P221 E224
Enzymatic activity
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7uiq, PDBe:7uiq, PDBj:7uiq
PDBsum7uiq
PubMed35830796
UniProtQ9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)

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