Structure of PDB 7ufu Chain B Binding Site BS02

Receptor Information
>7ufu Chain B (length=1038) Species: 216816 (Bifidobacterium longum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FLKPEQQLERCRRIVRQRVDPHIHPSIAQLTVESYDIPGEPMPSDEFFAK
LDRGDIDFKPFMLGSEWGTTWGTVWFRLTGTVPAGYPKGKPLELILDLGW
YPHSCGGHIEGLVYRADGTAIKAVHPLNYWVPFMDAEGNAQVPVAEDGSF
TLYLEAASNPLLLGVPPFIETELGDHATGKPDEPYVFKSADLAEFDERYE
NYSVDLDVVSSLMEFADKQSPRYWQLAKALQRSLNAYDERNPESVEAARA
VLAGVLAKPANASAMNVSAIGHAHIDSAWLWPVRETRRKVARTVSNALAL
MDADPDFKYAMSSAQQYAWLEEDHPDIFKRMKRRIEEGRFIPVGGMWVEA
DGMLPAGESLIRQIAYGRKYFKEHLGVEPKGVWLPASFGYTGAWPQIARR
AGYEWFLTQKISWNDTTKFPHHSFMWEGIDGSRIFTHFPPADTYAAWCKV
QELDYAEKNFQDKDLSDRSLLLFGFGDGGGGPTRNMMEHLHRYENLEGVS
KVSIEEPNDFFDKAHQQLAENAGPEMPVWKGELYLELHRGTLTSQQDMKR
GCRQEESLLRTVEYLGAAAVLSDPEYVYPREELDRIWKTLLLNQFHDILP
GSAIAWVHREAREDYRRDLKRLAEIAQDMCAVLRKANPQADLLAEARISQ
FRNDGASWHANRINEPTDALSVLTQTLDNGRVLLANGVLSVTIEADGTIS
SLLDEEHGRELVPAGTRLGQYELLRDEPAVWDAWEIERESLLMANAVTGS
IESVNTENGAAQVHVHTADGDTVITTTITLRPGSHTLDFHADIDWHERER
FLKVDLPLGIVADQATYDCQYGLIRRPIVKNTASDEAKYESSTNRFAIIG
DAGYAAAVINGSVYGSDASPIAGNAAEGRDSGTMFRLSLLSAPTFPDPRT
DIGSHEFDWSVVADATVDRALDAAGVLNAPVLHDVPDITPLASIESVNGT
VVLDWMKLADDGSGDLIVRAYEAAGGQADAMLHVCPALAGASVHETNVLE
GDDLAADLPVALQDGRQNAEGATLHFGPFQLATLRITR
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain7ufu Chain B Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7ufu Cryo-EM Structure of Bl_Man38A nucleophile mutant in complex with mannose at 2.7 A
Resolution2.7 Å
Binding residue
(original residue number in PDB)		H275 D277 W280 Y445 D478 H597 D598
Binding residue
(residue number reindexed from 1)		H274 D276 W279 Y444 D477 H596 D597
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004559 alpha-mannosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006013 mannose metabolic process
GO:0009313 oligosaccharide catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7ufu, PDBe:7ufu, PDBj:7ufu
PDBsum7ufu
PubMed
UniProtQ8G4Q1

[Back to BioLiP]