Structure of PDB 7t91 Chain B Binding Site BS02

Receptor Information
>7t91 Chain B (length=62) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKA
QYMLVVHMRRHT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7t91 Chain B Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7t91 Crystal structure of Zinc finger motif 1 and 2 of GLI1 DNA binding region
Resolution2.05 Å
Binding residue
(original residue number in PDB)		C270 C275 H291 H295
Binding residue
(residue number reindexed from 1)		C36 C41 H57 H61
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0008270 zinc ion binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7t91, PDBe:7t91, PDBj:7t91
PDBsum7t91
PubMed
UniProtP08151|GLI1_HUMAN Zinc finger protein GLI1 (Gene Name=GLI1)

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