Structure of PDB 7t37 Chain B Binding Site BS02

Receptor Information
>7t37 Chain B (length=619) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPPPMESPFQREDRNSPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKY
LTDSAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKLLVNA
QCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGT
CFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVM
IADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKLAAKE
GKIEIFRHILQREFSGPYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNS
VLEIIAFHCKSPNRHRMVVLEPLNKLLQEKWDRLVSRFFFNFACYLVYMF
IFTVVAYHQPSLFGESMLLLGHILILLGGIYLLLGQLWYFWRRRFMDSYF
EILFLLQALLTVLSQVLRFMETEWYLPLLVLSLVLGWLNLLYYTRGFQHT
GIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARAPYRSILDA
SLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMS
ETVNHVADNSWSIWKLQKAISVLEMENGYWWCRRKKHREGRLLKVGTPDE
RWCFRVEEVNWAAWEKTLP
Ligand information
Ligand IDFZ4
InChIInChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChIKeyBLZVCIGGICSWIG-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01
OpenEye OEToolkits 2.0.6		B(c1ccccc1)(c2ccccc2)OCCN
CACTVS 3.385NCCOB(c1ccccc1)c2ccccc2
FormulaC14 H16 B N O
Name2-aminoethyl diphenylborinate
ChEMBLCHEMBL169233
DrugBank
ZINCZINC000169743034
PDB chain7t37 Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7t37 Structural insights into TRPV2 activation by small molecules.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		R539 L542
Binding residue
(residue number reindexed from 1)		R467 L470
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell population proliferation
GO:0009266 response to temperature stimulus
GO:0045773 positive regulation of axon extension
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030424 axon
GO:0032584 growth cone membrane
GO:0042470 melanosome
GO:0044295 axonal growth cone
GO:0044297 cell body

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7t37, PDBe:7t37, PDBj:7t37
PDBsum7t37
PubMed35484159
UniProtQ9WUD2|TRPV2_RAT Transient receptor potential cation channel subfamily V member 2 (Gene Name=Trpv2)

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