Structure of PDB 7sq0 Chain B Binding Site BS02

Receptor Information
>7sq0 Chain B (length=302) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLPSLHDILDQHTYKWIFFGGKGGVGKTTTSSSFSVLMAETRPNEKFLLL
STDPAHNISDAFDQKFGKAPTQVSGIPNLYAMEVDASNEMKSAVAAAAAA
AAAAAAAAAAAATCASSFIKDGTFPGMDEMWSFINLIKLIDTNEYSTVIF
DTAPTGHTLRFLELPETVNKVLEIFTYPKIDVVKRISAEFRDPSLCTFVG
VCIPEFLSLYETERLVQRLAVLDMDCHAIVINFVLDANAATPCSMCRSRA
RMQNKYIDQINELYDDFNIVLSPLRHDEVRGIANLRDYAETLIKPYRFCW
SA
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain7sq0 Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7sq0 Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		G24 G26 T29 F277 L318
Binding residue
(residue number reindexed from 1)		G24 G26 T29 F233 L274
Annotation score5
Enzymatic activity
Enzyme Commision number 3.6.-.-
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
Biological Process
GO:0045048 protein insertion into ER membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sq0, PDBe:7sq0, PDBj:7sq0
PDBsum7sq0
PubMed35851188
UniProtA8B3G9|ASNA_GIAIC ATPase ASNA1 homolog (Gene Name=GL50803_7953)

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