Structure of PDB 7sbx Chain B Binding Site BS02

Receptor Information
>7sbx Chain B (length=1183) Species: 31631 (Human coronavirus OC43) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VIGDLKCPLDSRTGSLNNIPSISTATVDVTNGLGTYYVLDRVYLNTTLFL
NGYYPTSGSTYRNMALKGTDKLSTLWFKPPFLSDFINGIFAKVKNTKVFK
DGVMYSEFPAITIGSTFVNTSYSVVVQPRTINLQGLLEVSVCQYNMCEYP
HTICHPKLGNHFKELWHMDTGVVSCLYKRNFTYDVNATYLYFHFYQEGGT
FYAYFTDTGVVTKFLFNVYLGMALSHYYVMPLTCISRRDIGFTLEYWVTP
LTSRQYLLAFNQDGIIFNAVDCMSDFMSEIKCKTQSIAPPTGVYELNGYT
VQPIADVYRRKPDLPNCNIEAWLNDKSVPSPLNWERKTFSNCNFNMSSLM
SFIQADSFTCNNIDAAKIYGMCFSSITIDKFAIPNGRKVDLQLGNLGYLQ
SFNYRIDTTATSCQLYYNLPAANVSVSRFNPSTWNKRFGFIENSVFKPQP
AGVLTNHDVVYAQHCFKAPKNFCPCKLNSNGIGTCPAGTNYLTCHNLCNP
DPITFTGPYKCPQTKSLVGIGEHCSGLAVKSDYCGGNPCTCQPQAFLGWS
ADSCLQGDKCNIFANLILHDVNSGLTCSTDLQKANTDIKLGVCVNYDLYG
ISGQGIFVEVNATYYNSWQNLLYDSNGNLYGFRDYITNRTFMIRSCYSGR
VSAAFHANSSEPALLFRNIKCNYVFNNSLIRQLQPINYFDSYLGCVVNAY
NSTAISVQTCDLTVGSGYCVDYSKNTGYRFTNFEPFTVNSVNDSLEPVGG
LYEIQIPSEFTIGNMEEFIQTSSPKVTIDCAAFVCGDYAACKSQLVEYGS
FCDNINAILTEVNELLDTTQLQVANSLMNGVTLSTKLKDGVNFNVDDINF
SSVLGCLGASSRSAIEDLLFDKVKLSDVGFVAAYNNCTGGAEIRDLICVQ
SYKGIKVLPPLLSENQISGYTLAATSASLFPPWTAAAGVPFYLNVQYRIN
GLGVTMDVLSQNQKLIANAFNNALDAIQEGFDATNSALVKIQAVVNANAE
ALNNLLQQLSNRFGAISSSLQEILSRLDPPEAEAQIDRLINGRLTALNAY
VSQQLSDSTLVKFSAAQAMEKVNECVKSQSSRINFCGNGNHIISLVQNAP
YGLYFIHFSYVPTKYVTAKVSPGLCIAGDRGIAPKSGYFVNVNNTWMYTG
SGYYYPEPITENNVVVMSTCAVNYTKAPYVMLN
Ligand information
Ligand ID8Z9
InChIInChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h10-11H,2-9,12-15H2,1H3,(H,17,18)/b11-10-
InChIKeyNNNVXFKZMRGJPM-KHPPLWFESA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)CCCC\C=C/CCCCCCCCC
OpenEye OEToolkits 2.0.7CCCCCCCCCC=CCCCCC(=O)O
CACTVS 3.385CCCCCCCCC\C=C/CCCCC(O)=O
CACTVS 3.385CCCCCCCCCC=CCCCCC(O)=O
OpenEye OEToolkits 2.0.7CCCCCCCCC/C=C\CCCCC(=O)O
FormulaC16 H30 O2
NameSapienic acid
ChEMBL
DrugBank
ZINCZINC000085617707
PDB chain7sbx Chain A Residue 1410 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7sbx Structural mapping of antibody landscapes to human betacoronavirus spike proteins.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		N421 L422 G423
Binding residue
(residue number reindexed from 1)		N395 L396 G397
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046718 symbiont entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0055036 virion membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7sbx, PDBe:7sbx, PDBj:7sbx
PDBsum7sbx
PubMed35507649
UniProtA0A0B4N7I3

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