Structure of PDB 7s7c Chain B Binding Site BS02

Receptor Information
>7s7c Chain B (length=330) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENQELKRKLNILTRPSGILVNDTKLDGPILQILFMNNAISKQYHQEIEEF
VSNLVKRFEEQQKNDVEKTSFNLLPQPSSIVLEEDHKVEESCAIKNNKEA
FSVVGSVLYFTNFCLDKLGQPLLNENPQLSEGWEIPKYHQVFSHIVSLEG
QHCFNCGSEEHQMKDCPMPQQRYHAEEVEERFGRFKPGVISEELQDALGV
TDKSLPPFIYRMRQLGYPPGWLKEAELENSGLALYDGKSVTYDLSKLVNY
PGFNISTPRGIPDEWRIFGSIPMQACQQKDVFANYLPIPDMSKFATGITP
FEFENMAESTGMYLRIRSLLKNSPRNQQKN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7s7c Chain B Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7s7c Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex.
Resolution3.62 Å
Binding residue
(original residue number in PDB)		C229 C232 S234 H237 C242
Binding residue
(residue number reindexed from 1)		C153 C156 S158 H161 C166
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:7s7c, PDBe:7s7c, PDBj:7s7c
PDBsum7s7c
PubMed35688134
UniProtQ6NZY4|ZCHC8_HUMAN Zinc finger CCHC domain-containing protein 8 (Gene Name=ZCCHC8)

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