Structure of PDB 7s2k Chain B Binding Site BS02

Receptor Information
>7s2k Chain B (length=261) Species: 77133 (uncultured bacterium) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNKSLIIFGIVNITYLAPDAAIAQARKLMAEGADVIDLGPASSNPDAAPV
SSDTEIARIAPVLDALKADGIPVSLDSYQPATQAYALSRGVAYLNDIRGF
PDAAFYPQLAKSSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIA
ALTGAGIKRNRLVLDPGMGFFLGAAPETSLSVLARFDELRLRFDLPVLLS
VSRKSFLRALTGRGPGDVGAATLAAELAAAAGGADFIRTHEPRPLRDGLA
VLAALKETARI
Ligand information
Ligand IDPAB
InChIInChI=1S/C7H7NO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H,9,10)
InChIKeyALYNCZNDIQEVRV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Nc1ccc(cc1)C(O)=O
ACDLabs 10.04O=C(O)c1ccc(N)cc1
OpenEye OEToolkits 1.5.0c1cc(ccc1C(=O)O)N
FormulaC7 H7 N O2
Name4-AMINOBENZOIC ACID
ChEMBLCHEMBL542
DrugBankDB02362
ZINCZINC000000000920
PDB chain7s2k Chain B Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7s2k Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.
Resolution1.74 Å
Binding residue
(original residue number in PDB)		N53 R247 H249
Binding residue
(residue number reindexed from 1)		N44 R238 H240
Annotation score5
Enzymatic activity
Enzyme Commision number 2.5.1.15: dihydropteroate synthase.
Gene Ontology
Molecular Function
GO:0004156 dihydropteroate synthase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046656 folic acid biosynthetic process
GO:0046677 response to antibiotic
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7s2k, PDBe:7s2k, PDBj:7s2k
PDBsum7s2k
PubMed37419898
UniProtP0AC11|DHP2_ECOLX Dihydropteroate synthase type-2 (Gene Name=sulII)

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