Structure of PDB 7rxc Chain B Binding Site BS02

Receptor Information

>7rxc Chain B (length=439) Species: 1320,158879

LVIWINGDKGYNGLAEVGKKFKVTVEHPDKLEEKFPQVAPDIIFWAHDRF
GGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIY
NKDLLPNPPKTWEEIPALDKELKLMFNLQEPYFTWPLIAADGGYAFKYEN
GKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETA
MTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNK
ELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMEN
AQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDQALAFAQILIMPNLT
EEQRNGFIQSLKDDPSVSKEILAEAKKLNEHQAPTYKLVINGKTLKGETT
TKAVDAETAEKAFKQYANDNGVDGVWTYDDATKTFTVTE

Ligand information

• Ligand ID: GLC
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
• InChIKey: WQZGKKKJIJFFOK-DVKNGEFBSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  CACTVS 3.341: OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: alpha-D-glucopyranose;
  alpha-D-glucose;
  D-glucose;
  glucose
• ChEMBL: CHEMBL423707
• ZINC: ZINC000003861213
• PDB chain: 7rxc Chain A Residue 2

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7rxc Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies).
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): D66 R67 E154 P155 Y156 W341
• Binding residue (residue number reindexed from 1): D48 R49 E130 P131 Y132 W317
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0015144 carbohydrate transmembrane transporter activity
• GO:0019865 immunoglobulin binding

Biological Process

• GO:0008643 carbohydrate transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005618 cell wall

External links

• PDB: RCSB:7rxc, PDBe:7rxc, PDBj:7rxc
• PDBsum: 7rxc
• PubMed: 34620716
• UniProt: P06654;
  P99134