Structure of PDB 7riw Chain B Binding Site BS02

Receptor Information
>7riw Chain B (length=1126) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEDSTL
ILEQLRKYEISFGKIYVTKPMVNESDGVTHALYPQEARLRNLTYSSGLFV
DVKKRTYESGKVFIGRLPIMLRSKNCYLSEATESDLYKLKECPFDMGGYF
IINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSALEKGSRFIST
LQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICY
DVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRKEKRIQYAKDILQKEF
LPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAG
PLLAQLFKTLFKKLTKDIFRYMQRTVEELAINAKTITSGLKYALATGNWG
EQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGGKLAKPRQLHNTHW
GLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDY
VPHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDI
REKELKIFTDAGRVYRPLFIVEDDGHKELKVRKGHIAKLMATEYQDVEEY
TWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAELDVDPAKRIRVSHHA
TTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNY
NVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQ
EDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRM
KHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTPISAYHSKRDASTPLRSTE
NGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYR
REDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDAS
PFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRL
RHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAS
FLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIH
IPYAAKLLFQELMAMNITPRLYTDRS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7riw RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		S208 G506 T791 M792 R857 R942 G1121 R1122 S1123 R1129
Binding residue
(residue number reindexed from 1)		S155 G437 T706 M707 R772 R847 G1026 R1027 S1028 R1034
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003729 mRNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0006368 transcription elongation by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005739 mitochondrion
GO:0010494 cytoplasmic stress granule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7riw, PDBe:7riw, PDBj:7riw
PDBsum7riw
PubMed35022237
UniProtP08518|RPB2_YEAST DNA-directed RNA polymerase II subunit RPB2 (Gene Name=RPB2)

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