Structure of PDB 7rfk Chain B Binding Site BS02

Receptor Information
>7rfk Chain B (length=575) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DISQDNFLLSKEYENSLDVDTKKASGIYYTPKIIVDYIVKKTLKNHDIIK
NPYPRILDISCGCGNFLLEVYDILYDLFEENIYELKKKYDENYWTVDNIH
RHILNYCIYGADIDEKAISILKDSLTNKKVVNDLDESDIKINLFCCDSLK
KKWRYKFDYIVGNPPYIGHKKLEKKYKKFLLEKYSEVYKDKADLYFCFYK
KIIDILKQGGIGSVITPRYFLESLSGKDLREYIKSNVNVQEIVDFLGANI
FKNIGVSSCILTFDKKKTKETYIDVFKIKNEDICINKFETLEELLKSSKF
EHFNINQRLLSDEWILVNKDDETFYNKIQEKCKYSLEDIAISFQGIITGC
DKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIVDKSEYRLIYSNDIDN
ENTNKRILDEIIGLYKTKLENRRECKSGIRKWYELQWGREKLFFERKKIM
YPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDKFSYEYLVGILNSSVY
DKYFKITAKKMSKNIYDYYPNKVMKIRIFRDNNYEEIENLSKQIISILLN
KSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7rfk Repurposing epigenetic inhibitors to target the Clostridioides difficile- specific DNA adenine methyltransferase and sporulation regulator CamA.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		H171 K172 K176 K179 L183 D192 K193 K254 I349 G351 D353 K378 S379 K380 R425 Q438 W439 Y455 K456
Binding residue
(residue number reindexed from 1)		H169 K170 K174 K177 L181 D190 K191 K252 I347 G349 D351 K376 S377 K378 R423 Q436 W437 Y453 K454
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7rfk, PDBe:7rfk, PDBj:7rfk
PDBsum7rfk
PubMed34523387
UniProtQ183J3

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