Structure of PDB 7r3y Chain B Binding Site BS02

Receptor Information
>7r3y Chain B (length=1102) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLT
NMHATLVSQEQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVND
VEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFE
ARKLLRPILQDNANNNVQRNIYNVDAKHLIEDIREYDVPYHVRVSIDKDI
RVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAVDQIM
MISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALL
QRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAE
GEYKSSYCSHMDCFRWLKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELM
TPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLR
KGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVE
SLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTN
FEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSI
TCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNLTFDELSYADQVIH
IKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFRDRRYEF
KGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAHKVILNSFYGYV
MRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDTDGIWCILP
KSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIY
ETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELKGF
ELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVLDSHG
LMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLGEDMVKD
KGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTLDPSLED
LDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKRKI
AT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7r3y Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		D1028 D1031
Binding residue
(residue number reindexed from 1)		D944 D947
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r3y, PDBe:7r3y, PDBj:7r3y
PDBsum7r3y
PubMed35822874
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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