Structure of PDB 7r1f Chain B Binding Site BS02

Receptor Information
>7r1f Chain B (length=728) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEY
SNKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEH
PGLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITS
FRLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLPAFLIKRI
PMKVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIRGFVLV
VENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGISMTVTG
DNTKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIARLGKG
FMITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEEGTASL
SPGMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALFVNAKD
EETCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDGFVSNF
AMELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQLFIADY
RYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYNLRNLH
IPEIVLKYNLMDPEYKGRLLHPQNPFVGHLSIMDYDAVSGTHSWRTKRNR
SILNTDQRNMILEEQCYAKCCNLFEACFNSASYRKPVGQHSMLEAMAHRL
RMDARLDYESGRMSKDDFEKAMAHLGEI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7r1f Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		R126 Q127 N136 K229 D230 I241 A242 R249 E256 P272 G274 G275 K353 M410 G411 M415 I524 N531
Binding residue
(residue number reindexed from 1)		R127 Q128 N137 K225 D226 I237 A238 R245 E252 P268 G270 G271 K349 M406 G407 M411 I520 N527
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r1f, PDBe:7r1f, PDBj:7r1f
PDBsum7r1f
PubMed36596301
UniProtQ5V8Y6

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