Structure of PDB 7qtl Chain B Binding Site BS02

Receptor Information
>7qtl Chain B (length=717) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPTLLFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHKYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEIVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMDSMDKEEMEITTHKKKQRLNKRSYLIRAL
TLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVEALARSICEKLEQSGLP
VGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMI
TYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQVPAEM
LANIDLKYFNKSTREKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVS
ILNLGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKL
VGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESAD
MSVGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRR
AFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQG
RLCNPMNPFVSHKEISMEYDAVATTHSWIPKRNRSNTSQRGILEDEQMYQ
KCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEF
AEIMKICSTIEELRRQK
Ligand information
Receptor-Ligand Complex Structure
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PDB7qtl Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Resolution2.48 Å
Binding residue
(original residue number in PDB)		Y30 G125 R126 Q127 R135 N136 M227 K229 I241 A242 T243 R249 R260 P272 G274 K353 Q367 P369 M409 G410 M411 N413 T528 N532
Binding residue
(residue number reindexed from 1)		Y30 G125 R126 Q127 R135 N136 M205 K207 I219 A220 T221 R227 R238 P250 G252 K331 Q345 P347 M387 G388 M389 N391 T506 N510
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qtl, PDBe:7qtl, PDBj:7qtl
PDBsum7qtl
PubMed36596301
UniProtM9TLW3

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