Structure of PDB 7qbt Chain B Binding Site BS02

Receptor Information

>7qbt Chain B (length=408) Species: 2214 (Methanosarcina acetivorans)

MEVVVDVGGNPGVDCKGFCKYCYFKKVKDIQPLGCKYCLPFKKGCDYCTR
SVKESYSGFKSLQMVLEETANKLYFTEVKKFTVSGGGDLSCYPELKSLIT
FLSQFNTPIHLGYTSGKGFSKPDDALFYIDNGVTEVSFTVFATDPALRAE
YMKDPEPEASIQVLRDFCTHCEVYGAIVLLPGINDGEVLEKTLCDLENMG
AKGAILMRFANFQENGLILNNSPIIPGITPHTVSEFTEIVRSSAEKHPSI
RITGTPLEDPLIGSPFAIRNVPEALLKLPRVSKKATIITGQVAASRLTEI
FEALGGTVNVIPVKKDIGCLITIDDFKALDLSEVTETVFIPGRAFVHDME
IKEALRRDGVDRIVRRGPERLSVDGEMSIGMTREEVLELEVENFTELIGQ
INSLGLPL

Ligand information

• Ligand ID: FE
• InChI: InChI=1S/Fe/q+3
• InChIKey: VTLYFUHAOXGGBS-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Fe+3]
• Formula: Fe
• Name: FE (III) ION
• DrugBank: DB13949
• PDB chain: 7qbt Chain B Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qbt Crystallographic snapshots of a B 12 -dependent radical SAM methyltransferase.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): C35 C38 C45 C48
• Binding residue (residue number reindexed from 1): C35 C38 C45 C48
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.1.1.379: [methyl coenzyme M reductase]-L-arginine C-5-methyltransferase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0008168 methyltransferase activity
• GO:0035244 protein-arginine C-methyltransferase activity
• GO:0046872 metal ion binding
• GO:0051536 iron-sulfur cluster binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0032259 methylation
• GO:0043687 post-translational protein modification

External links

• PDB: RCSB:7qbt, PDBe:7qbt, PDBj:7qbt
• PDBsum: 7qbt
• PubMed: 35110733
• UniProt: Q8THG6|MCRAM_METAC [Methyl coenzyme M reductase]-L-arginine C-5-methyltransferase (Gene Name=MA_4551)