Structure of PDB 7pks Chain B Binding Site BS02

Receptor Information
>7pks Chain B (length=1112) Species: 9825 (Sus scrofa domesticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAP
PIDLQPPRYLLKFEQIYLSKPTHWDGAPSPMMPNEARLRNLTYSAPLYVD
ITKTVQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGG
YFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTS
TIWVSMLARQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFED
PEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQ
KEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLD
LAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGL
KYSLATGNWGDARAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQ
LHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSM
ENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNN
YSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHP
SMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHV
LYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSA
VDRGFFRSVFYRSYKEQESKKQEEVFEKPTRETCQGMRHAIYDKLDDDGL
IAPGVRVSGDDVIIGKTVTLPERRYTKRDCSTFLRTSETGIVDQVMVTLN
QEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGIT
PDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKIS
NLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSR
ARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASD
PYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQEL
MSMSIAPRMMSV
Ligand information
Receptor-Ligand Complex Structure
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PDB7pks Structural basis of Integrator-mediated transcription regulation.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		E516 Q731 H842 R886 P1066
Binding residue
(residue number reindexed from 1)		E466 Q681 H789 R824 P1004
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pks, PDBe:7pks, PDBj:7pks
PDBsum7pks
PubMed34762484
UniProtA0A0B8RVL1

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