Structure of PDB 7p8v Chain B Binding Site BS02

Receptor Information
>7p8v Chain B (length=331) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGG
AKLIRIRDNGCGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALA
SISSVSRLTLTSRTAEQQEAWQAYAEGRDMNVTVKPAAHPVGTTLEVLDL
FYNTPARRKFLRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYR
AVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWVADPNHTTPAL
AEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVD
VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQ
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7p8v Chain B Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7p8v MutL binds to 3' resected DNA ends and blocks DNA polymerase access.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		E29 N33
Binding residue
(residue number reindexed from 1)		E29 N33
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0030983 mismatched DNA binding
GO:0042802 identical protein binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0000018 regulation of DNA recombination
GO:0000717 nucleotide-excision repair, DNA duplex unwinding
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0070716 mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
Cellular Component
GO:0017117 single-stranded DNA-dependent ATP-dependent DNA helicase complex
GO:0032300 mismatch repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7p8v, PDBe:7p8v, PDBj:7p8v
PDBsum7p8v
PubMed35670670
UniProtP23367|MUTL_ECOLI DNA mismatch repair protein MutL (Gene Name=mutL)

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