Structure of PDB 7opd Chain B Binding Site BS02

Receptor Information
>7opd Chain B (length=1131) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPP
IDLQAPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLY
VDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELN
ECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCL
ENSSRPTSTIWVSMLARGAIGQRIVATLPYIKQEVPIIIVFRALGFVSDR
DILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTK
EKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRREL
DDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLE
LAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLSHL
RRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYI
SVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQ
LMNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQK
LLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDL
QEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQA
MGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAI
ASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKP
TRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPRYTKRDCS
TFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKG
TCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANK
GEIGDATPFNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFI
GPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDC
QIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGCRNK
TQISLVRMPYACKLLFQELMSMSIAPRMMSV
Ligand information
>7opd Chain P (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auauauacaaaaucgagagga
.....................
Receptor-Ligand Complex Structure
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PDB7opd Structural basis of human transcription-DNA repair coupling.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		A464 G465 Q468 R841 H842 K934 K942 H1053
Binding residue
(residue number reindexed from 1)		A432 G433 Q436 R809 H810 K891 K899 H1010
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7opd, PDBe:7opd, PDBj:7opd
PDBsum7opd
PubMed34526721
UniProtI3LGP4

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