Structure of PDB 7ol3 Chain B Binding Site BS02

Receptor Information

>7ol3 Chain B (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KKAGPVQVLIVKDDHSFELDETALNRILLSEAVRDKEVVAVSVAGAFRKG
KSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIWSEI
FLINKPDGKKVAVLLMDTQGTFDSQSTLRDSATVFALSTMISSIQVYNLS
QNVQEDDLQHLQLFTEYGRLAMEETFLKPFQSLIFLVRDWSFPYEFSYGA
DGGAKFLEKRLKVSGNQHEELQNVRKHIHSCFTNISCFLLPHPGLKVATN
PNFDGKLKEIDDEFIKNLKILIPWLLSPESLDIKEINGNKITCRGLVEYF
KAYIKIYQGEELPHPKSMLQATAEANNLAAVATAKDTYNKKMEEICGGDK
PFLAPNDLQTKHLQLKEESVKLFRGVKKMGGEEFSRRNYLQQLESEIDEL
YIQYIKHNDSKNIFHAARAAALEHH

Ligand information

Ligand ID

ALF

InChI

InChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4

InChIKey

UYOMQIYKOOHAMK-UHFFFAOYSA-J

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	F[Al-](F)(F)F

Formula

Al F4

Name

TETRAFLUOROALUMINATE ION

PDB chain

7ol3 Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7ol3 A novel insertion mutation in atlastin 1 is associated with spastic quadriplegia, increased membrane tethering, and aberrant conformational switching.
Resolution	1.9 Å
Binding residue (original residue number in PDB)	F76 R77 K80 R118 E119 T120 G149
Binding residue (residue number reindexed from 1)	F47 R48 K51 R89 E90 T91 G120
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.6.5.-

Gene Ontology

	Molecular Function
GO:0003924	GTPase activity
GO:0005525	GTP binding

View graph for
Molecular Function

External links

PDB	RCSB:7ol3, PDBe:7ol3, PDBj:7ol3
PDBsum	7ol3
PubMed	34808209
UniProt	Q8WXF7\|ATLA1_HUMAN Atlastin-1 (Gene Name=ATL1)

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