Structure of PDB 7mvs Chain B Binding Site BS02

Receptor Information
>7mvs Chain B (length=675) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEK
ARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHI
RTLLLTFFYRFMRPLIEAGYVYIAQPPTGYKGLGEMNADQLWETTMNPEH
RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANSRINERNIT
SEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTPDKSYK
KSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDG
DGAAAMRFTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFP
NLLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEG
PDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQRIVVTEIP
FQVNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRKDANAS
VILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRR
RTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRF
KLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETILADEEVL
LQLVRDELTEIRDRFGDDRRTEIQL
Ligand information
Receptor-Ligand Complex Structure
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PDB7mvs Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA.
Resolution2.60137 Å
Binding residue
(original residue number in PDB)		K10 G29 D30 S31 R51 G52 D105 R234 H247 H280 H282 G283 S286 R293 I376
Binding residue
(residue number reindexed from 1)		K1 G20 D21 S22 R42 G43 D96 R218 H231 H264 H266 G267 S270 R277 I360
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:7mvs, PDBe:7mvs, PDBj:7mvs
PDBsum7mvs
PubMed34614347
UniProtP0A0K8|GYRB_STAAU DNA gyrase subunit B (Gene Name=gyrB);
P20831

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