Structure of PDB 7mib Chain B Binding Site BS02

Receptor Information
>7mib Chain B (length=338) Species: 243231 (Geobacter sulfurreducens PCA) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLPLYVQSPKAYVRKDGDCLVIEEERVRVAEARLGETSQVALFGNATLTT
AALHECLRREIPVTWLSYGGWFMGHTVSTGHRNVETRTYQYQRSFDPETC
LNLARRWIVAKIANCRTLLRRNWRGEGDEAKAPPGLLMSLQDDMRHAMRA
PSLEVLLGIEGASAGRYFQHFSRMLRGGDGEGMGFDFTTRNRRPPKDPVN
ALLSFAYAMLTREWTVALAAVGLDPYRGFYHQPRFGRPALALDMMEPFRP
LIADSTVLMAINNGEIRTGDFVRSAGGCNLTDSARKRFIAGFERRMEQEV
THPIFKYTISYRRLLEVQARLLTRYLSGEIPAYPNFVT
Ligand information
>7mib Chain H (length=64) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ctgtgccgtccgtaacgttgtcgatttttgtattccggggccatgatgcc
ccggcctcattgaa
Receptor-Ligand Complex Structure
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PDB7mib Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.
Resolution5.8 Å
Binding residue
(original residue number in PDB)		Y288 R412 R413 P415 R454 R457 N499
Binding residue
(residue number reindexed from 1)		Y68 R192 R193 P195 R234 R237 N279
Enzymatic activity
Enzyme Commision number 3.1.-.-
3.1.12.1: 5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:7mib, PDBe:7mib, PDBj:7mib
PDBsum7mib
PubMed34588691
UniProtQ74H36|CS4F1_GEOSL CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion (Gene Name=cas4-cas1)

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