Structure of PDB 7mi5 Chain B Binding Site BS02

Receptor Information
>7mi5 Chain B (length=340) Species: 243231 (Geobacter sulfurreducens PCA) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRGLPLYVQSPKAYVRKDGDCLVIEEERVRVAEARLGETSQVALFGNATL
TTAALHECLRREIPVTWLSYGGWFMGHTVSTGHRNVETRTYQYQRSFDPE
TCLNLARRWIVAKIANCRTLLRRNWRGEGDEAKAPPGLLMSLQDDMRHAM
RAPSLEVLLGIEGASAGRYFQHFSRMLRGGDGEGMGFDFTTRNRRPPKDP
VNALLSFAYAMLTREWTVALAAVGLDPYRGFYHQPRFGRPALALDMMEPF
RPLIADSTVLMAINNGEIRTGDFVRSAGGCNLTDSARKRFIAGFERRMEQ
EVTHPIFKYTISYRRLLEVQARLLTRYLSGEIPAYPNFVT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7mi5 Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.
Resolution3.57 Å
Binding residue
(original residue number in PDB)		P229 K230 N265 S287 Y288 G289 W291 M293 S424 F425 R505
Binding residue
(residue number reindexed from 1)		P11 K12 N47 S69 Y70 G71 W73 M75 S206 F207 R287
Enzymatic activity
Enzyme Commision number 3.1.-.-
3.1.12.1: 5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:7mi5, PDBe:7mi5, PDBj:7mi5
PDBsum7mi5
PubMed34588691
UniProtQ74H36|CS4F1_GEOSL CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion (Gene Name=cas4-cas1)

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