Structure of PDB 7md4 Chain B Binding Site BS02

Receptor Information

>7md4 Chain B (length=778) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDICPGTQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLG
NCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHH
KCKCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKT
IDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKI
RRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLT
ITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCEN
ELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVVVDID
PPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDI
IYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQ
AEDSELFELDYCLKGLKLPSREEHRPFEKVVNKESLVISGLRHFTGYRIE
LQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMW
QEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNY
SVRIRATSLAGNGSWTEPTYFYVTDYLD

Ligand information

>7md4 Chain U (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GIVEQCCTSICSLYQLENYCN

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7md4 Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.
Resolution	4.5 Å
Binding residue (original residue number in PDB)	R488 P537 L538 N547
Binding residue (residue number reindexed from 1)	R468 P502 L503 N512

Enzymatic activity

Enzyme Commision number

2.7.10.1: receptor protein-tyrosine kinase.

External links

PDB	RCSB:7md4, PDBe:7md4, PDBj:7md4
PDBsum	7md4
PubMed	35177603
UniProt	P06213\|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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