Structure of PDB 7luf Chain B Binding Site BS02

Receptor Information
>7luf Chain B (length=1054) Species: 10298 (Human alphaherpesvirus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NFYNPYLAPVGPTQRHTYYSECDEFRFIAPRVLDEDAPPEKRAGVHDGHL
KRAPKVYCGGDERDVLRVGSGGFWPRRSRLWGGVDHAPAGFNPTVTVFHV
YDILENVEHAYGMRAAQFHARFMDAITPTGTVITLLGLTPEGHRVAVHVY
GTRQYFYMNKEEVDRHLQCRAPRDLCERMAAALRESPGASFRGISADHFE
AEVVERTDVYYYETRPALFYRVYVRSGRVLSYLCDNFCPAIKKYEGGVDA
TTRFILDNPGFVTFGWYRLKPGRNNTLAQPRAPMAFGTSSDVEFNCTADN
LAIEGGMSDLPAYKLMCFDIACKAGGEDELAFPVAGHPEDLVIQISCLLY
DLSTTALEHVLLFSLGSCDLPESHLNELAARGLPTPVVLEFDSEFEMLLA
FMTLVKQYGPEFVTGYNIINFDWPFLLAKLTDIYKVPLDGYGRMNGRGVF
RVWDIGQSHFQKRSKIKVNGMVNIDMYGIITDKIKLSSYKLNAVAEAVLK
DKKKDLSYRDIPAYYAAGPAQRGVIGEYCIQDSLLVGQLFFKFLPHLELS
AVARLAGINITRTIYDGQQIRVFTCLLRLADQKGFILPDTQRHVGYQGAR
VHDPTSGFHVNPVVGFDFASLYPSIIQAHNLCFSTLSLRADAVAHLEAGK
DYLEIEVGGRRLFFVKAHVRESLLSILLRDWLAMRKQIRSRIPQSSPEEA
VLLDKQQAAIKVVCNSVYGFTGVQHGLLPCLHVAATVTTIGREMLLATRE
YVHARWAAFEQLLADFPEAADMRAPGPYSMRIIYGDTDSIFVLCRGLTAA
GLTAMGDKMASHISRALFLPPIKLECEKTFTKLLLIAKKKYIGVIYGGKM
LIKGVDLVRKNNCAFINRTSRALVDLLFYDDTVSGAAAALAERPAEEWLA
RPLPEGLQAFGAVLVDAHRRITDPERDIQDFVLTAELSRHPRAYTNKRLA
HLTVYYKLMARRAQVPSIKDRIPYVIVAQTREVEETVARLAALREVSELA
EDPAYAIAHGVALNTDYYFSHLLGAACVTFKALFGNNAKITESLLKRFIP
EVWH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7luf Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		K534 D888 K939 Y941 K953 G954 R959 E1036 R1039 Y1044 T1045 N1046 R1071
Binding residue
(residue number reindexed from 1)		K485 D788 K839 Y841 K853 G854 R859 E936 R939 Y944 T945 N946 R971
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0005515 protein binding
GO:0008409 5'-3' exonuclease activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication
Cellular Component
GO:0042025 host cell nucleus
GO:0042575 DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7luf, PDBe:7luf, PDBj:7luf
PDBsum7luf
PubMed34031403
UniProtP04293|DPOL_HHV11 DNA polymerase catalytic subunit (Gene Name=UL30)

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