Structure of PDB 7lt5 Chain B Binding Site BS02

Receptor Information
>7lt5 Chain B (length=576) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDISQDNFLLSKEYENSLDVDTKKASGIYYTPKIIVDYIVKKTLKNHDII
KNPYPRILDISCGCGNFLLEVYDILYDLFEENIYELKKKYDENYWTVDNI
HRHILNYCIYGADIDEKAISILKDSLTNKKVVNDLDESDIKINLFCCDSL
KKKWRYKFDYIVGNPPYIGHKKLEKKYKKFLLEKYSEVYKDKADLYFCFY
KKIIDILKQGGIGSVITPRYFLESLSGKDLREYIKSNVNVQEIVDFLGAN
IFKNIGVSSCILTFDKKKTKETYIDVFKIKNEDICINKFETLEELLKSSK
FEHFNINQRLLSDEWILVNKDDETFYNKIQEKCKYSLEDIAISFQGIITG
CDKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIVDKSEYRLIYSNDID
NENTNKRILDEIIGLYKTKLENRRECKSGIRKWYELQWGREKLFFERKKI
MYPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDKFSYEYLVGILNSSV
YDKYFKITAKKMSKNIYDYYPNKVMKIRIFRDNNYEEIENLSKQIISILL
NKSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lt5 Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix.
Resolution2.54 Å
Binding residue
(original residue number in PDB)		H171 K172 K176 K179 L183 D192 K193 K254 I349 D353 K378 K380 R425 Q438 W439 Y455 K456
Binding residue
(residue number reindexed from 1)		H170 K171 K175 K178 L182 D191 K192 K253 I348 D352 K377 K379 R424 Q437 W438 Y454 K455
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7lt5, PDBe:7lt5, PDBj:7lt5
PDBsum7lt5
PubMed34103525
UniProtQ183J3

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