Structure of PDB 7lml Chain B Binding Site BS02

Receptor Information
>7lml Chain B (length=212) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAMAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGG
GPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQ
IPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEK
GVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRA
LRTAPIQPRVWE
Ligand information
Ligand IDY6S
InChIInChI=1S/C9H6INO2/c10-6-2-1-5-3-8(9(12)13)11-7(5)4-6/h1-4,11H,(H,12,13)
InChIKeyLLSYKFHQMUBJCF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385OC(=O)c1[nH]c2cc(I)ccc2c1
OpenEye OEToolkits 2.0.7c1cc(cc2c1cc([nH]2)C(=O)O)I
FormulaC9 H6 I N O2
Name6-iodanyl-1~{H}-indole-2-carboxylic acid
ChEMBL
DrugBank
ZINCZINC000002443762
PDB chain7lml Chain B Residue 306 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lml A fragment-based approach to discovery of Receptor for Advanced Glycation End products inhibitors.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		L49 Q100
Binding residue
(residue number reindexed from 1)		L30 Q81
Annotation score1
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:7lml, PDBe:7lml, PDBj:7lml
PDBsum7lml
PubMed34156100
UniProtQ15109|RAGE_HUMAN Advanced glycosylation end product-specific receptor (Gene Name=AGER)

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